Translation, Implementation & Links

The third strategic pillar of the ON TRACK Network is to facilitate the dissemination and timely implementation of research into clinical practice. Here we highlight recent clinical trials research that has been supported by the ON TRACK Network and multicentre trials that have been published within the last few years that may have implications on your practice. We also provide links to important clinical practice guidelines that should inform and influence your practice, research guidelines and links to useful websites.

Clinical Trial Publications

Preterm Infants

Preterm Infants

2018      Tottman AC, Alsweiler JM, Bloomfield FH, Gamble G, Jiang Y, Leung M, et al. Long-Term Outcomes of Hyperglycemic Preterm Infants Randomized to Tight Glycemic Control. J Pediatr. 2018 Feb;193:68-75.e1. doi: 10.1016/j.jpeds.2017.09.081. Epub 2017 Dec 1. https://www.ncbi.nlm.nih.gov/pubmed/29198539

 

Low Birth Weight Infants

Low Birth Weight Infants

2020    Tarnow-Mordi WO, Abdel-latif ME, Martin A, et al.  The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double blind, randomised controlled trial. The Lancet Child & Adolescent Health. 2020 June 01; 4(6): 444-454. https://doi.org/10.1016/S2352-4642(20)30093-6.

Childhood Outcomes

Childhood Outcomes

2017      McKinlay CJD, Cutfield WS, Battin MR, Dalziel SR, Crowther CA, Harding JE, et al. Mid-childhood bone mass after exposure to repeat doses of antenatal glucocorticoids: A Randomized Trial. Pediatrics. 2017 May;139(5). pii: peds.2016-4250. doi: 10.1542/peds.2016-4250. Epub 2017 Apr 7. http://www.ncbi.nlm.nih.gov/pubmed/28557758

2016      Crowther CA, Anderson PJ, McKinlay CJ, Harding JE, Ashwood PJ, Haslam RR, et al. Mid-childhood outcomes of repeat antenatal corticosteroids: A Randomized Controlled Trial. Pediatrics. 2016 Oct;138(4). pii: peds.2016-0947. doi: 10.1542/peds.2016-0947. Epub 2016 Sep 20.  http://www.ncbi.nlm.nih.gov/pubmed/27650051

2016      Harris DL, Alsweiler JM, Ansell JM, Gamble GD, Thompson B, Wouldes TA, et al. Outcome at 2 Years after Dextrose Gel Treatment for Neonatal Hypoglycemia: Follow-Up of a Randomized Trial. J Pediatr. 2016 Mar;170:54-9.e1-2. doi: 10.1016/j.jpeds.2015.10.066. Epub 2015 Nov 21. http://www.ncbi.nlm.nih.gov/pubmed/26613985 

Pregnancy

Pregnancy

2019      Okesene-Gafa KAM, Li M, McKinlay CJD, Taylor RS, Rush EC, Wall CR, et al. Effect of antenatal dietary interventions in maternal obesity on pregnancy weight-gain and birthweight: Healthy Mums and Babies (HUMBA) randomized trial. Am J Obstet Gynecol. 2019 Mar 13. pii: S0002-9378(19)30478-8. doi: 10.1016/j.ajog.2019.03.003. https://www.ncbi.nlm.nih.gov/pubmed/30878323

Fetal Growth Restriction

Fetal Growth Restriction

2019      Groom KM, McCowan LM, Mackay LK, Lee AC, Gardener G, Unterscheider J, Sekar R, Dickinson JE, Muller P, Reid RA, Watson D, Welsh A, Marlow J, Walker SP, Hyett J, Morris J, Stone PR, Baker PN. STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early‐onset fetal growth restriction. BJOG. 2019;126(8):997-1006. https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.15658

2019      Cartwright RD, Crowther CA, Anderson PJ, Harding JE, Doyle LW, McKinlay CJD. Association of Fetal Growth Restriction with neurocognitive function after repeated antenatal betamethasone treatment vs placebo: Secondary analysis of the ACTORDS Randomized Clinical Trial. JAMA Netw Open. 2019 Feb 1;2(2):e187636. doi: 10.1001/jamanetworkopen.2018.7636. https://www.ncbi.nlm.nih.gov/pubmed/30707225

2017      Groom KM, McCowan LM, Mackay LK, Lee AC, Said JM, Kane SC, et al. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial. Am J Obstet Gynecol. 2017 Mar;216(3):296.e1-296.e14. doi: 10.1016/j.ajog.2017.01.014. Epub 2017 Jan 30. http://www.ncbi.nlm.nih.gov/pubmed/28153659

2017      Pels A, Kenny LC, Alfirevic Z, Baker PN, von Dadelszen P, Gluud C, et al. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Pregnancy Childbirth. 2017;17(1):440. BMC Pregnancy Childbirth. 2017 Dec 28;17(1):440. doi: 10.1186/s12884-017-1594-z. http://www.ncbi.nlm.nih.gov/pubmed/29282009

Preterm Birth

Preterm Birth

2020 Poppe T, Thompson B, Boardman JP, Bastin ME, Alsweiler J, Deib G, Harding JE, Crowther CA. Effect of antenatal magnesium sulphate on MRI biomarkers of white matter development at term equivalent age: The magnum study. EBio Medicine 2020. https://doi.org/10.1016/j.ebiom.2020.102957

2019      Crowther CA, Ashwood P, Andersen CC, Middleton PF, Tran T, Doyle LW, et al. Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial. The Lancet Child & Adolescent Health. 2019. https://doi.org/10.1016/S2352-4642(19)30292-5

2017      Crowther CA, Ashwood P, McPhee AJ, Flenady V, Tran T, Dodd JM, et al. Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial. PLoS Med. 2017 Sep 26;14(9):e1002390. doi: 10.1371/journal.pmed.1002390. eCollection 2017 Sep http://www.ncbi.nlm.nih.gov/pubmed/28949973

Clinical Practice Publications

Obstetrics & Midwifery

Clinical Practice - Obstetrics & Midwifery

2019       Gatman K, May R, Crowther C. Survey on use of antenatal magnesium sulphate for fetal neuroprotection prior to preterm birth in Australia and New Zealand – Ongoing barriers and enablers. Australian New Zealand Journal of Obstetrics and Gynaecology 2019. https://www.ncbi.nlm.nih.gov/pubmed/31119725

2019       Dawes, L; Buksh, M; Sadler, L; Waugh, J; Groom K. Perinatal care provided for babies born at 23 and 24 weeks of gestation. Aust NZ J Obstetrics Gynaecology. 2019 Nov 27. doi: 10.1111/ajo.13094. https://www.ncbi.nlm.nih.gov/pubmed/31774934

2018      Dawes LK, Subramoney M, Miller LM, Groom KM. Increasing compliance with a clinical practice guideline for fetal fibronectin testing and the management of threatened preterm labour: A quality improvement project. Eur J Obstet Gynecol Reprod Biol. 2018;221:89-96. https://www.ncbi.nlm.nih.gov/pubmed/29275278 

2018       Tuohy J, Harding J, Crowther C, Bloomfield F. Reported adherence to current antenatal corticosteroid guidelines in Australia and New Zealand. Australian New Zealand Journal of Obstetrics and Gynaecology. 2018. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/ajo.12890

Neonatal

Clinical Practice - Neonatal

2019      Alexander T, Bloomfield FH. Nutritional management of moderate-late preterm infants: Survey of current practice. J Paediatr Child Health. 2019;55(3):338-42. https://www.ncbi.nlm.nih.gov/pubmed/30152042

2019      Cloete E, Gentles TL, Dixon LA, Webster DR, JD A, Davidkova S, et al. Feasibility study assessing equitable delivery of newborn pulse oximetry screening in New Zealand's midwifery led maternity setting. BMJ Open. 2019. https://bmjopen.bmj.com/content/9/8/e030506

2019      Cloete E, Gentles TL, Webster DR, Davidkova S, Dixon LA, Alsweiler JM, et al. Pulse oximetry screening in a midwifery-led maternity setting with high antenatal detection of congenital heart disease. Acta Paediatr. 2019. Acta Paediatr. 2019 Jul 12. doi: 10.1111/apa.14934. https://www.ncbi.nlm.nih.gov/pubmed/31298757

2019       Muelbert M, Harding JE, Bloomfield FH. Nutritional policies for late preterm and early term infants - can we do better? Semin Fetal Neonatal Med. 2019;24(1):43-7. Semin Fetal Neonatal Med. 2019 Feb;24(1):43-47. doi: 10.1016/j.siny.2018.10.005. Epub 2018 Oct 12. https://www.ncbi.nlm.nih.gov/pubmed/30341037

2018       Alsweiler J, Woodall S, Crowther C, Harding J. Oral dextrose gel to treat neonatal hypoglycaemia: Clinician survey. Journal of Paediatrics and chikd Health. 2018. https://onlinelibrary.wiley.com/doi/10.1111/jpc.14306

2018       Oglivy-Stuart A, Harding J, Beardsall K. Thresholds for hypoglycaemic screening – a cause for concern? Arch Dis Child. 2018. https://ep.bmj.com/content/104/1/33.full

Clinical Practice Guidelines

The following guidelines have been informed and developed by clinical research involving New Zealand mothers and babies.

Research Guidelines

newsletter

New Zealand Health Research Strategy

newsletter

NEAC Maori Research Ethics an Overview

newsletter

HRC Maori Health Advancement Guidelines

newsletter

Te Ara Tika Guidelines for Maori Research Ethics

newsletter

Guidelines for Researchers on Health Research involving Maori

newsletter

Medsafe guideline on clinical trials

newsletter

National ethical standards health disability research

Websites


The Perinatal Society of New Zealand (PSNZ) is a multidisciplinary group dedicated to advancing all aspects of perinatology in New Zealand.

The Perinatal Society of Australia and New Zealand (PSANZ) is a multidisciplinary society dedicated to improving the health and long term outcomes for mothers and their babies. PSANZ encompasses and strongly encourages research focused on mothers and babies during pregnancy and at birth as well as the health of the newborn as its development continues after birth.

The Australian Clinical Trials Alliance (ACTA) supports and represents networks of clinician researchers conducting investigator-initiated clinical trials, clinical quality registries and clinical trial coordinating centres in Australia. A wide range of clinical trials resources is available on their website.

International Society for Evidence-Based Neonatology (EBNEO) is a non-profit organisation with a vision that all neonatal care should be firmly built on best available evidence.

The Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) provide consultative leadership and advocacy in women's health.

The Midwifery Council of New Zealand provides information, education and resources to expectant parents and midwives for protecting the health and safety of women and babies during pregnancy, childbirth and during the first six weeks after a baby is born.

The New Zealand College of Midwives is New Zealand's professional organisation for midwives. The College's Joan Donley Midwifery Research Collaboration (JDMRC) is the evidence arm of the College and provides support for the College’s research programme.

The New Zealand Maternal and Fetal Medicine Network was established in 2009 with support from the Ministry of Health to promote excellent Maternal Fetal Medicine (MFM) Services around New Zealand and support maternity healthcare providers in District Health Boards.